NEPHROPROTECTIVE EFFECT OF ETHANOLIC EXTRACT O F BALAKKA ( PHYLLANTHUS EMBLICA L.) ON RATS INDUCED ETHYLENE GLYCOL A ND AMMONIUM CHLORIDE

PIYANTO HALIM (2019) NEPHROPROTECTIVE EFFECT OF ETHANOLIC EXTRACT O F BALAKKA ( PHYLLANTHUS EMBLICA L.) ON RATS INDUCED ETHYLENE GLYCOL A ND AMMONIUM CHLORIDE , TESIS, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

The kidneys are a pair of symmetrical organs that function to filter the blood and are

located  in  the  retroperitoneal region  on  the  posterior  wall  of  the  abdomen.  The  kidneys  are

drained about 25% of cardiac output. Kidney damage due to the accumulation of kidney stones

can  be  caused  by  ethylene  glycol  substances  to  form  calcium  oxalate  crystals  (CaC2O4).  This crystal  iscommon  in  urine  specimens  even  in  healthy  animals.  Crystal  formation  can  be accelerated  by  the  administration  of  ammonium  chloride.  This  study  aims  to  determine  the

nephroprotective  effects  of  balakka  ethanol  extract to  reduce  creatinine  and  urea  levels  in  rats

induced  by  ethylene  glycol  and  ammonium  chloride.  The  results  showed  that  the  balakka ethanol  extract  with  a  dose  variation  of  50  mg/kg  body  weight,  100  mg/kg  body  weight,  and 150 mg/kg body weight had nephroprotective activity in rats that had been induced by ethylene glycol  and  ammonium  chloride.  Where  the  induction  group  had  the  largest  serum  creatinine mean of 1.43 mg/dl. The ethanolic extract of balakka(EEB) treatment group dose of 50 mg/kgBWhad a  serum creatinine  value of 1.01 mg/dl. The EEB treatment group dose of 100 mg/kg BWhad a serum value of 0.91 mg/dl. The balakka ethanol extracttreatment group dose of 150 mg/kg  BWhad  a  serum  value  of  0.73 mg/dl.  The  induction  group  had  the  largest  serum  urea serum  of  76.56  mg/dl.  EEB  treatme

nt  group  dose  of  50 mg/kg  BWhad  serum  urea  value  of 63.36 mg/dl. The EEB treatment group dose of 100 mg/kg BWhad a serum urea value of 49.73 mg/dl.  The balakka  ethanol  extract treatment  group  dose  of  150 mg/kg  BWhad  a  serum  urea value of 49.90 mg/dl.

JURNAL
KATEGORI JURNAL Jurnal Nasional
TAHUN JURNAL 2019
VOLUME JURNAL 2
NOMOR JURNAL 2
NAMA PENERBIT Indonesian Journal of Pharmaceutical and Clinical Research
NOMOR ISSN/ISBN 26156199
LAMAN PENERBIT (URL) https://talenta.usu.ac.id/idjpcr/index
LAMAN ARTIKEL (URL) https://talenta.usu.ac.id/idjpcr/article/view/3207/2470