Psoriasis is a persistent inflammatory dermatosis marked by keratinocyte hyperproliferation and immune system dysfunction. This study aimed to evaluate the anti-psoriasis potential of Sorghum bicolor extract in imiquimod (IMQ) induced psoriasis BALB/c mice. An ethanolic extract of Sorghum bicolor was prepared and subjected to phyto- chemical screening, antioxidant assays (DPPH), and quantification of total phenolics and flavonoids. A total of 30 male BALB/c mice were divided into six groups (n=5 per group) and treated over 7 days. Furthermore, skin of BALB/c mice was topically induced with IMQ to develop psoriasis-like lesions animal model and divided into six groups: normal control, IMQ-only, methotrexate-treated, and three groups receiving S. bicolor extract at doses of 70, 140, and 210 mg/ kg BW orally. Evaluations included PASI scoring, histopathological examination using Trozak’s Score, measurement of interleukin-17 (IL-17) and tumor necrosis factor-alpha (TNF-α) cytokine levels, and superoxide dismutase (SOD) ac- tivity. Phytochemical analysis detected of several bioactive compounds such as alkaloids, tannins, polyphenols, saponins, flavonoids, steroids, and terpenoids. The extract exhibited high antioxidant activity (IC50 = 80.13 μg/mL) and contained high levels of total phenolics (81.85 mg GAE/g) and flavonoids (6.36 mg QE/g). Treatment significantly reduced PASI scores (G6: 1.4 ± 0.55 vs. IMQ control: 6.8 ± 0.45; P ≤ 0.0001) and Trozak score analysis showed highest S. bicolor extract improved psoriasis-like histological features in IMQ-induced mice (P ≤ 0.05), suggesting potential for skin integrity restoration. S. bicolor extract increased SOD levels (G6: 4.15 ± 1.29 ng/mL; P ≤ 0.05) but induced statistically insignificant changes in IL-17 levels and a moderate elevation in TNF-α at higher doses. These findings suggest that S. bicolor extract exerts potential anti-psoriasis effects primarily via antioxidant mechanisms.