THE EFFECT OF ADMINISTRATION OF ROSELLA FLOWER (HIBISCUS SABDARIFFA) EXTRACT GEL ON THE EXPRESSION OF TNF-Α AND CASPASE-3 EXPRESSION IN AN IN VIVO STUDY OF WISTAR STRAIN RATS EXPOSED TO ULTRAVIOLET B-LIGHTS
DYAH NISMA PURBONINGTYAS (2024) THE EFFECT OF ADMINISTRATION OF ROSELLA FLOWER (HIBISCUS SABDARIFFA) EXTRACT GEL ON THE EXPRESSION OF TNF-Α AND CASPASE-3 EXPRESSION IN AN IN VIVO STUDY OF WISTAR STRAIN RATS EXPOSED TO ULTRAVIOLET B-LIGHTS , TESIS, UNIVERSITAS PRIMA INDONESIA
ABSTRAK
Since it can produce reactive oxygen species and free radical compounds, ultraviolet light has
oxidative properties. Skin aging such as photoaging can occur due to excessive sun exposure.
Because of its flavonoids that function as antioxidants as well as free radical scavengers, the
usefulness of rosella petals can be used in medicine, jam, and natural food coloring. This
experimental study investigated how Rosella flower extract gel (Hibiscus sabdariffa L.) affects
the expression of TNF-α and Caspase-3 in UVB-exposed Wistar rats. The total study sample
was 24 samples, with 6 samples for each treatment group Descriptive, normality, and
homogeneity tests were used in data analysis with data processing using SPSS 25.0 for
Windows. The results have shown that UVB-exposed rats showed lower expression of TNF-α
and Caspase-3 with 15% concentration of rosella flower extract gel, which resulted in denser
and filled collagen. These results suggest that rosella flower extract gel may serve as an
antioxidant that stops the expression of these two types of proteins..
JURNAL
| KATEGORI JURNAL | Jurnal Internasional |
|---|---|
| TAHUN JURNAL | 2024 |
| VOLUME JURNAL | 3 |
| NOMOR JURNAL | 2 |
| NAMA PENERBIT | International Journal of Public Health Excellence (IJPHE) |
| NOMOR ISSN/ISBN | 2809-9826 |
| LAMAN PENERBIT (URL) | https://ejournal.ipinternasional.com/index.php/ijphe |
| LAMAN ARTIKEL (URL) | https://ejournal.ipinternasional.com/index.php/ijphe/article/view/753 |