UJI AKTIVITAS HEPATOPROTEKTIF EKSTRAK ETHANOL BUAH MENGKUDU (MORINDA CITRIFOLIA) PADA TIKUS YANG DIINDUKSI DOKSORUBISIN
ROZANA ARIFIN (2020) UJI AKTIVITAS HEPATOPROTEKTIF EKSTRAK ETHANOL BUAH MENGKUDU (MORINDA CITRIFOLIA) PADA TIKUS YANG DIINDUKSI DOKSORUBISIN , TESIS, UNIVERSITAS PRIMA INDONESIA
ABSTRAK
The liver is the largest solid organ, the largest gland and one of the most vital organs that functions as a center for
nutrient metabolism and excretion of waste metabolites. In general, the biological effects caused by the use of
Anthracycline doxorubicin are the occurrence of apoptosis, necrosis, and autophagy. The purpose of this study was
to determine the hepatoprotective activity of Mengkudu Fruit Ethanol Extract against the rats induced by
doxorubicin. Mengkudu Fruit Ethanol Extract was obtained by maceration. hepatoprotective activity test is done by
measuring AST and ALT. Animals were induced with DOX 5 mg/kg BW on day 1,7,14 and 20 th . Administration of
Mengkudu extract 100 mg / kg BW, 300 mg / kg BW, and 500 mg / kg BW given from day 1 to day 20 and on the
21st day cardiac serum levels of AST and ALT. mengkudu dose of 100 mg/kg BW, 300 mg/kg BW and 500 mg/kg
BW have hepatoprotective activity against male rats induced by doxorubicin. mengkudu shows activity as a
hepatoprotection. mengkudu doses of 100, 300 and 500 mg/kg BW can inhibit the increase in ALT and AST activity.
mengkudu dose 100 mg/kg BW with AST 334.33 U/L and ALT 152 U/L, mengkudu dose 300 mg/kg BW with AST
304.33 U/L and ALT 117.33 U/L, and mengkudu dose 500 mg/kg BW with AST 192.67 U/L and ALT 103.67 U/L
showed significant differences (p <0.05) against the negative control group. mengkudu doses of 100, 300, and 500
mg/kg BW can reduce ALT and AST in doxorubicin-induced male rats.
JURNAL
| KATEGORI JURNAL | Jurnal Internasional |
|---|---|
| TAHUN JURNAL | 2020 |
| VOLUME JURNAL | 5 |
| NOMOR JURNAL | 2 |
| NAMA PENERBIT | Journal of Innovations in Applied Pharmaceutical Science |
| NOMOR ISSN/ISBN | 24555177 |
| LAMAN PENERBIT (URL) | https://saap.org.in/journals/index.php/jiaps/index |
| LAMAN ARTIKEL (URL) | https://saap.org.in/journals/index.php/jiaps/article/view/202 |