EFFICACY OF GINGER (ZINGIBER OFFICINALE) AND CELERY (APIUM GRAVEOLENS L.) EXTRACTS ON HAIR GROWTH IN WISTAR RATS (RATTUS NORVEGICUS)

MAYLIA LIE (2024) EFFICACY OF GINGER (ZINGIBER OFFICINALE) AND CELERY (APIUM GRAVEOLENS L.) EXTRACTS ON HAIR GROWTH IN WISTAR RATS (RATTUS NORVEGICUS) , TESIS, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

Ginger (Zingiber officinale) and Celery (Apium graveolens L.) are widely recognized for their medicinal properties, including anti-inflammatory and antioxidant effects. Both have been traditionally used to address various health issues, including hair loss. Despite their widespread use, scientific evidence supporting their effectiveness in promoting hair growth is limited. This study aims to evaluate the effects of Ginger and Celery extracts on hair growth using a Wistar rat model, with a focus on their impact on hair growth onset, duration, and regrowth, as well as their potential inflammatory effects on the skin. Method: A total of 25 Wistar rats were randomly divided into five groups: control (paraffin), Ginger extract, Celery extract, a combination of Ginger and Celery extracts, and a treatment group receiving both extracts. Each extract was administered at a dosage of 20 mg/ml. The study involved monitoring hair growth onset, duration, and regrowth scores. Histological examinations were performed to assess hair follicle density and inflammation levels. Phytochemical analyses of the extracts were conducted to identify the presence of flavonoids, alkaloids, glycosides, saponins, tannins, and steroids/triterpenoids. Result: Phytochemical analysis revealed that Ginger contained flavonoids, alkaloids, glycosides, and steroids/triterpenoids, while Celery contained flavonoids, alkaloids, saponins, tannins, glycosides, and steroids/triterpenoids. Statistical analysis using ANOVA showed no significant differences in the onset and duration of hair growth, or hair regrowth scores, between the treatment groups and the control group. Histological analysis indicated that the average number of hairs ranged from 4 to 10 per field of view, with the highest count observed in the Ginger extract group and the lowest in the Celery extract group. Most slides showed light or no inflammation. Conclusion: At the tested dosage, neither Ginger nor Celery extracts significantly influenced the onset or duration of hair growth or hair regrowth in the Wistar rat model. Histological findings suggested minimal inflammatory responses across the groups. These results indicate that while both extracts possess phytochemicals with known biological activities, they do not significantly impact hair growth or regeneration at the given dosage. Further research with different dosages and additional compounds is recommended to explore their full therapeutic potential for hair growth and skin health.

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