FORMULATION AND PHYSICAL STABILITY ANALYSIS OF RED BEETROOTS (BETA VULGARIS L.) EFFERVESCENT GRANULES

JOVIN FRIANDO, MAI THAO PHUONG, LE HONG HAI, CUT CYNTHIA LUZRIA (2023) FORMULATION AND PHYSICAL STABILITY ANALYSIS OF RED BEETROOTS (BETA VULGARIS L.) EFFERVESCENT GRANULES , SKRIPSI, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

Introduction: Red beetroots (Beta vulgaris L.) are a natural ingredient rich in nutrients and provides various notable health benefits such as mediating cardiology effect, antioxidant, anti-inflammation, anti-tumor and antibacterial. In dentistry, red beetroots have the potential as a plaque-disclosing agent. Several studies showed significant drawbacks of red beetroots preparation in gels or chewable forms. Therefore, this study aimed to analyze the ideal formula and evaluate the physical stability of effervescent granules made from red beetroots extract (Beta vulgaris L.) in different doses. Methods: This study was experimental, descriptive research conducted from August 2022 to January 2023. Instruments used were a digital stopwatch, digital balance sheet, blender, stirring rod, erlenmeyer, vial, measuring cup, rotary rotavapor, vortex, oven, knife, pH paper, calipers, plastic bottle, glass bottle, aluminum foil, a container for granulation process, mortar, stamper, granulate tool tester, sieve mesh. The extract obtained was made into effervescent granules using the granulation method. The formulation of effervescent granules contains 8.8% of citric acid, 17.6% of tartaric acid, 30.2% of sodium bicarbonate, 1% aspartame, 1% PVP, 1% aerosil. The amount of lactose is based on the concentration of red beetroots extract formulation in each sample. After the formulation of granules, physical stability tests were carried out, including a flow rate test, density test, dissolution time, and pH test. Result: At 1% and 3% concentrations, red beetroots effervescent granules passed all the physical stability tests and revealed a relatively good result. Meanwhile, the 4% red beetroots extract formula showed poorer results than the other two concentrations and failed two physical tests. Conclusion: F1 (1%) and F2 (3%) have the best formulation and physical stability of all three formulas. F2 (3%) and F3 (4%) are potential for alternating plaque disclosing agents.

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