TEST THE EFFECTIVENESS OF RED BETEL LEAF EXTRACT CREAM FOR HEALING BURNS ON THE BACK WISTAR STRAIN WHITE RAT

MUSTIKA HIDAYATTI (2023) TEST THE EFFECTIVENESS OF RED BETEL LEAF EXTRACT CREAM FOR HEALING BURNS ON THE BACK WISTAR STRAIN WHITE RAT , TESIS, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

A wound is a state of damage to normal anatomical function and structure. There are various types of wounds, including acute wounds (scratches, burns, trauma, needle sticks, and surgical incisions obtained in health care settings) and chronic wounds (diabetic foot ulcers or pressure ulcers). Red betel leaves contain flavonoids, alkaloids, polyphenolics, tannins and essential oils, where the main components of red betel leaf essential oil consist of phenols and derivative compounds such as kavikol, eugenol, kavibetol, tannins, saponins, allylpyrocatechol which contain antiseptic and antifungal substances. This study

 aims to analyze and test the effectiveness of administering red betel leaf extract cream (Piper crocatum) in the healing process of burns on the backs of Wistar white rats (Rattus norvegicus). With the control group, this study used a pre-test. Twenty white samples were used. The samples were divided into four groups, each group consisting of five animals. Oil in water (O/W) is used to make red cream, and maceration is used to extract betel leaves. Fibroblastic cell growth was observed to determine its histology macroscopically. A two x two cm mouse biopsy was used to begin the procedure. One Way ANOVA test was used to show differences between groups (p<0.05), and the Shapiro-Wilk test was used to show data validity (p<0.05). Post hoc analysis was carried out using the LSD method to find out which treatment group was more effective. In this study, the results showed that the group given 15% red betel leaf extract cream was more effective in healing burns in white rats compared to the group given 7.5% and 10% betel leaf extract cream. This is because at a concentration of 15%, the secondary metabolite compounds in red betel leaf extract already have an effect on wounds, but at small concentrations they only inhibit microorganisms so they are less effective in healing wounds. The reduction in wound area in cream preparations is better than in gel dosage forms because cream preparations contain an oil phase and a water phase in their components so they will stick to the skin longer than gel preparations which only contain water-soluble ingredients so the effect produced by cream is higher than gel.

JURNAL