EFEKTIVITAS GEL EKTRAK RIMPANG KUNYIT (CURCUMA DOMESTICA VALET) TERHADAP LUKA BAKAR DERAJAT IIA PADA TIKUS PUTIH (RATTUS NOVERGICUS)

RISYAD RIZKI MAULIDI (2022) EFEKTIVITAS GEL EKTRAK RIMPANG KUNYIT (CURCUMA DOMESTICA VALET) TERHADAP LUKA BAKAR DERAJAT IIA PADA TIKUS PUTIH (RATTUS NOVERGICUS) , TESIS, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

ABSTRACT

This study aims to determine the acceleration of burn wound healing in rats given
ethanol extract of turmeric rhizome (Curcuma Domestica Valet) gel and to see the
granulation of the skin histopathology of rats. This research method is experimental
with a post-test only design. The research location is in the UNPRI Bio-Molecular
Laboratory with 24 rat samples. Treated with Turmeric Rhizome Extract Gel with
Concentrations of 25%, 50%, 75% and 100% and Silver Sulvadizine as Positive
Control and Gel as Negative Control. The results showed that the effectiveness of
the best Turmeric Rhizome Extract Gel for wound healing was a concentration of
100% on the 21st day of 15 mm. the worst diameter was the negative control on the
21st day of 20 mm. This happens healing in burns because of the content of tannins
and flavonoids. Measurement of the diameter of the granulation tissue on the
histopathological picture with the results of a concentration of 100% with a
thickness of 863 m. Hypothesis test Ha is accepted There is Effectiveness of Ethanol
Extract of Turmeric Rhizome Extract (Curcuma Domestica VALET) in Healing
Grade IIA Burns. Suggestion It is necessary to do further research related to the
factors that cause weak anti-inflammatory and antibiotic Kunit rhizome Extract Gel
against second-degree burns

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