NEPHROPROTECTIVE EFFECT OF ETHANOL EXTRACT OF CARICA PAPAYA SEED ON RATS INDUCED RIFAMPICIN AND ISONIAZID
ETTY KARTIKA CHANDRA (2021) NEPHROPROTECTIVE EFFECT OF ETHANOL EXTRACT OF CARICA PAPAYA SEED ON RATS INDUCED RIFAMPICIN AND ISONIAZID , TESIS, UNIVERSITAS PRIMA INDONESIA
ABSTRAK
Tuberculosis (TB) is an airborne, completely curable
infection. The most common type is referred to as pulmonary TB.
Rifampicin (RIF) is the first-line therapy for tuberculosis along with
isoniazid (INH), ethambutol (ETB), and pyrazinamide (PZA). Papaya
seeds are known to contain high concentrations of polyphenols,
flavonoids, triterpenoids, tannins, saponins, alkaloids, glycosides,
reducing sugars, steroids, proteins, lipids, anthraquinones, and
anthocyanosides. The RIF is the most commonly prescribed anti-TB
drug and most studies associate it with acute kidney injury. In this study,
papaya seed ethanol extract was treated with different doses. For the
test, eight groups of rats were used: normal, negative 1, negative 2,
negative 3, positive, treatment I (100 mg/kg BW), treatment II (100
mg/kg BW), 300 mg/kg BW), and treatment III (500 mg/kg BW). After
dissection of the mice, serum whey protein concentrations were
measured. The results showed that compared to the negative control
group, papaya seed ethanol extract significantly reduced urea,
creatinine, uric acid, and creatinine clearance (<P0.05).
PROSIDING
| KATEGORI PROSIDING | Prosiding Internasional |
|---|---|
| LOKASI PROSIDING | Medan |
| TANGGAL MULAI KONFERENSI | 2021-10-06 |
| TANGGAL SELESAI KONFERENSI | 2021-10-08 |
| NAMA PENERBIT | IOP Conf. Series: Earth and Environmental Science |
| NOMOR ISSN/ISBN | 1083012068 |
| LAMAN PENERBIT (URL) | https://iopscience.iop.org/ |
| LAMAN ARTIKEL (URL) | https://iopscience.iop.org/article/10.1088/1755-1315/1083/1/012068 |