Coping mechanisms are how individuals solve problems, adapt to change, and respond to threatening situations. This study aims to determine the factors associated with the coping mechanisms of chronic kidney failure (CKD) clients undergoing hemodialysis therapy at Fatmawati Hospital in 2009 namely client education, client knowledge, gender, expectations of self-efficacy, optimism, and social support. . The research design was cross-sectional. The population in this study were CKD clients who underwent hemodialysis therapy. Samples were taken as many as 72 respondents using the two-proportion difference hypothesis test formula with a simple random sampling method. Data collection was done by using a questionnaire. The data analysis used was univariate and bivariate in the form of chi-square test, bivariate correlation test, and binary logistic regression test. The results of this study indicate that not all of the factors studied have a significant effect on the coping mechanisms of CKD clients undergoing hemodialysis therapy. The related variables were gender (p-value = 0.013) and the expectation of self-efficacy (p-value = 0.007). while the unrelated variables are knowledge, education, optimism, and social support. From the results of the study, it was found that the coping mechanism