THE EFFECT OF ETHANOL EXTRACT OF CARICA PAPAYASEED TOWARDS LIPID PROFILE ON RATS INDUCED RIFAMPICIN AND ISONIAZID

LIANA (2021) THE EFFECT OF ETHANOL EXTRACT OF CARICA PAPAYASEED TOWARDS LIPID PROFILE ON RATS INDUCED RIFAMPICIN AND ISONIAZID , TESIS, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

Aims:

Rifampicin one of the most commonly used front

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line drugs in antituberculosis therapy, has been known to be hepatotoxic. The oxidative stress that is formed in the mitochondria due to rifampicin and isoniazid causes an imbalance in lipid metabolism. This study aims to determine the effect of lowering total cholesterol, triglyceride, and LDL levels and increasing HDL levels of papaya seed ethanol extract in rats induced by rifampin and isoniazid.

Study

design:

This study is experimental study.

Methodology:

This study was divided into 9 groups including normal group, negative group 1, 2, 3,

positive 1, 2, treatment group I (EECP 100 mg/kgbw), treatment group II (EECP 300 mg/kgbw), and

treatment group III

(EECP 500 mg/kgbw). Rifampicin (50 mg/kgbw), isoniazid (50 mg/kgbw), and EECP were given 28 days, on day 29 rats were dissected and blood was taken and the total cholesterol, triglyceride, LDL and HDL levels were measured.

Results:

The results showed that the ethanol extract of papaya seeds at a dose of 100 mg / kgbb, 300 mg / kgbb, and 500 mg / kgbw could reduce levels of total cholesterol, triglycerides, LDL and increase HDL levels. The dose of 500 mg / kgbw was not statistically significant (P> 0.05) with the normal group

 Conclusion: Ethanol extract of Carica papaya has a potential effect of preventing the destruction of lipid metabolism effect by reducing the LDL, Trygliseride, Cholesterol Total, and increasing the level of HDL

JURNAL
KATEGORI JURNAL Jurnal Internasional
TAHUN JURNAL 2021
VOLUME JURNAL 33
NOMOR JURNAL 41
NAMA PENERBIT Journal of Pharmaceutical Research International
NOMOR ISSN/ISBN 24569119
LAMAN PENERBIT (URL) https://www.journaljpri.com/index.php
LAMAN ARTIKEL (URL) https://journaljpri.com/index.php/JPRI/article/view/3138