CARDIAC PROTECTIVE ACTIVITY OF ETHANOL EXTRACT WHITE CURCUMIN(CURCUMA ZEDOARIA) INDUCED CYCLOPHOSPHAMID IN MALE SPRAGUE DEWLEY MICE

ADDIN AMRULLAH (2021) CARDIAC PROTECTIVE ACTIVITY OF ETHANOL EXTRACT WHITE CURCUMIN(CURCUMA ZEDOARIA) INDUCED CYCLOPHOSPHAMID IN MALE SPRAGUE DEWLEY MICE , TESIS, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

Drug side effect reactions that can also be associated with cyclophosphamide administration are bone marrow suppression, exposure to infections and amenorrhoea as well as toxic kidney poisoning and cystitis, as well as cardiovascular complications such as sinus bradycardia, pericarditis, myocarditis and heart problems 1. A natural resource that can be used as an alternative solution to reduce the side effects of cyclophosphamide is Curcuma zedoaria due to the presence of curcumin. This study aims to determine the extent of protection of Curcuma zedoaria against cyclophosphamide in rat hearts using 4 indicators, namely; CKMB enzymes, peripheral blood, troponin T and cardiac cell histopathology. This research was conducted using 30 rats which were divided into 6 groups consisting of a normal group (without treatment), a negative control group (Na-CMC 0.5%), a positive control group (catechins), and 3 experimental groups given the extract. white turmeric rhizome ethanol with various doses. Each group of rats was given 150 mg / kg of cyclophosphamide solution on days 11 to 15 of the experiment. The results showed that the CKMB and troponin T levels decreased with increasing doses of Curcuma Zedoaria given to mice. Leukocyte levels decreased with increasing doses of Curcuma Zedoaria given to mice. Erythrocyte levels in each group were within the normal range except for the negative group. Platelet levels in each group were within the normal range except for the negative group and the 200mg / kgbb turmeric dose group. Meanwhile, the lymphocyte levels in each group were within the normal range. The histopathological picture shows improvement where the cariorexis and caryolysis features that occur less and less with increasing doses, especially those of 800 mg / kgbb. Curcuma zedoaria given to mice. All experimental groups suffered from active inflammation. Curcuma zedoaria has a protective effect against excessive cyclophosphamide exposure in mice, but does not completely protect mice from the effects of overexposure. Key words: Curcuma zedoaria; cyclophosphamide; curcumin; CKMB: Peripheral blood: histopathology

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