EVALUATION OF HONEY EFFECTIVITY ON BURNED-WOUND CONTRACTION IN RATTUS NORVEGICUS

NUR AIDAH (2021) EVALUATION OF HONEY EFFECTIVITY ON BURNED-WOUND CONTRACTION IN RATTUS NORVEGICUS , TESIS, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

Burns are sores on the skin caused by chemicals, hot water, or fire. Most people take the wrong approach to burn treatment, such as applying toothpaste or oil. Honey is one of the natural ingredients that is often used for the treatment of burns which ensures different pharmacological properties. In this study, the ability of honey to heal partial burns was tested using 27 male wistar rats (Rattus norvegicus) as experimental subjects. In the experiment, a post-test only control group design was chosen. The experimental rats were divided into three groups: honey, silver sulfadiazine, and control. The rats burns were intentionally created using a 1.2 x 1.2 cm steel plate heated with solder. Features under observation were contraction and burn photography. The median (range) or mean SD was used to present all data. In the observation period, on the fifth, seventh, and ninth days, there was a significant difference in wound contraction between the honey and silver sulfadiazine groups (P value 0.173, 0.012, 0.146). However, in the last two days, wound contraction increased in the honey and silver sulfadiazine groups (P value 0.598). Finally, after five days of treatment, it can be stated that honey has significant wound healing effectiveness. 

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