REDUCTION OF TROPONIN LEVELS IN RATS THROUGH CARDIOPROTECTIVE ACTIVITY OF SYZYGIUM POLYANTHUM ETHANOL EXTRACT

DANIEL AGUSTINUS TEDDY SOEMIJARTO (2021) REDUCTION OF TROPONIN LEVELS IN RATS THROUGH CARDIOPROTECTIVE ACTIVITY OF SYZYGIUM POLYANTHUM ETHANOL EXTRACT , TESIS, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

 

 Benzene is a pollutant that has a very high exposure to humans, and this is because it is widely used as a solvent in industries. Furthermore, this compound is known to cause cardiovascular disease which can damage the structure and function of the heart when exposed for a long time. This study aims to determine the cardioprotective potential of the ethanolic extract of Syzygium polyanthum in benzene-induced rats. This was carried out in a laboratory using rats as experimental animals. Syzygium polyanthum extract was administered to the rats according to their specific doses 400, 600, 800 mg/kgbw during 21 days of experiment while benzene given in every 3 dan 6 days. On the 21 day rats were sacrified and blood is taken directly from cardiac rat then analysis the levels of Troponin T and BNP. The results showed that the ethanolic extract of Syzygium polyanthum at doses of 400, 600, 800 mg/kgbw could reduce Tropinin T and BNP levels on rats. In addition, futher studies can be carried out on the high sensitive C reactive protein and also explore the molecular mechanism of the cardioprotective effect of Syzygium polyanthum ethanol extract.

 

PROSIDING

KATEGORI PROSIDING	Prosiding Internasional
LOKASI PROSIDING	MEDAN
TANGGAL MULAI KONFERENSI	2021-07-14
TANGGAL SELESAI KONFERENSI	2021-07-16
NAMA PENERBIT	IEEE Xplore
NOMOR ISSN/ISBN	9781665441827
LAMAN PENERBIT (URL)	http://ieeexplore.ieee.org/
LAMAN ARTIKEL (URL)	http://ieeexplore.ieee.org/document/9537281