ANTIHYPERLIPIDEMIA EFFECT OF SYGYZIUM POLYANTHUM ETHANOL EXTRACT ON BENZENE INDUCED RATS

TONDY (2021) ANTIHYPERLIPIDEMIA EFFECT OF SYGYZIUM POLYANTHUM ETHANOL EXTRACT ON BENZENE INDUCED RATS , TESIS, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

Abstract—Hyperlipidemia is an important risk factor for atherosclerotic cardiovascular disease, including cerebrovascular disease, coronary heart disease, and peripheral arterial disease. Benzene is bad for life and health at 500 ppm, exposure to 20,000 ppm benzene for 5-10 minutes in the air is fatal and oral doses are estimated at 9-30 grams proven to be harmful. Syzygium polyanthum (Wight) Walp. or known as Syzygium polyanthum is a species of the Myrtaceae family which is used as a traditional medicine by various ethnicities, especially in Southeast Asia such as Malaysia and Indonesia which has high antioxidant activity. This study aims to determine the effect of giving ethanol extract of Syzygium polyanthum to rats induced by benzene. The results showed that. Ethanol extract of Syzygium polyanthum at doses of 400, 600, and 800 mg/kgbw could reduce cholesterol, triglyceride, and LDL levels and increase HDL levels, which were significantly different at p<0.05 in the benzene-only group. Ethanol extract of Syzygium polyanthum can increase SOD levels and decrease MDA levels. It can be concluded that the ethanol extract has high antioxidant benefits to prevent the radicalization process.

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