WOUND HEALING ACTIVITY OF MANGKOKAN LEAVES EXTRACT OINTMENT

JESSIE MERYANI (2021) WOUND HEALING ACTIVITY OF MANGKOKAN LEAVES EXTRACT OINTMENT , TESIS, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

Burns is still a challenge for health workers and one of the global community's main health problems. Many synthetic drugs are used as wound treatment, but it has high cost and much side effects. Hence, this study was designed to explore the wound healing activity from mangkokan leaves (Polyscias Scutellarian.). This study was an experimental study using 25 male Wistar rats grouped into five different groups: control (Ointment base), standard (Nebacetin ®), 12.5%, 25%, and 50% mangkokan leaves extract ointment. The mangkokan leaves ointment was made of mangkokan leaves ethanol extract, which was obtained by maceration. Two parameters were analyzed viz. wound contraction and epithelialization period. The result showed that on the 15th day, the highest wound contraction was found in 25% mangkokan leaves extract ointment group (80.97%), followed by the 50% (79.46%), 12.5% (67.19%), the standard (65.86%), and the control group (55.46%). Meanwhile, the longest period of epithelialization was found in the control group (14 days) followed by the 50% (13 days), 25% (12 days), standard (12 days), and 12.5% mangkokan leaves ointment (10 days). Overall, it can be concluded that the lowest concentration (12.5%) of ointment already has wound healing activity.

PROSIDING