ASSOCIATION BETWEEN BODY MASS INDEX (BMI) AND DNA FRAGMENTATION INDEX

KENDY G. (2021) ASSOCIATION BETWEEN BODY MASS INDEX (BMI) AND DNA FRAGMENTATION INDEX , TESIS, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

One of the underlying mechanisms of sperm cell DNA damage is oxidative stress. People with overweight or obese tend to high oxidative stress in plasma and urine. Due to this reason, this study was aimed to investigate the association between body mass index and DNA Fragmentation Index in male partners from infertile couples at Halim Fertility Center’s Stella Maris Mother’s and Children’s Hospital. This study is an observational study with a cross-sectional design among 40 male partners from infertile couples at Halim Fertility Center’s Stella Maris Mother’s and Children’s Hospital selected by convenience sampling. This study showed a positive, very strong correlation between Body Mass Index and DNA Fragmentation index (P-value < 0.05; R2=0.998). Half of the male couples as samples have a body mass index value between 19.50-28.33 kg/m2 and DNA fragmentation index of 2.00-11.50%, while the remaining half show a body mass index value of >28.33 – 34.72 kg/m2 and DNA fragmentation index between > 11.50-44.00%. Thus, it can be concluded that body mass index affects the DNA Fragmentation Index value in the infertile couple.

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