ANALYSIS OF WOUND HEALING ACTIVITY FROM ROSE PETAL EXTRACT OINTMENT IN WISTAR RATS

SWASTINA PINKY LATCUBA (2021) ANALYSIS OF WOUND HEALING ACTIVITY FROM ROSE PETAL EXTRACT OINTMENT IN WISTAR RATS , TESIS, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

Basic Health Report (2013) reported that burn was sixth-ranked in unintentional injury. The rose petal has various pharmacologic effects that promote wound healing activity. Therefore, this study was aimed to investigate burn wound healing activity on the rose petal as an ointment. This study was an experimental study using 25 male Wistar rats grouped into five different groups: control (Ointment base), standard (Nebacetin ®), 7.5%, 10%, and 15% rose petal ointment. The rose petal ointment was made of rose petals methanol extract, which was obtained by maceration. Two parameters evaluated wound contraction and epithelialization period; moreover, the skin was also excised for histology study. The highest wound contraction was found in the standard group (87.47%), followed by 15% (85.07%), 10% (73.33%), 7.5% (69.16%) rose petal ointment, and control group (64.27%). Meanwhile, the epithelialization period of each treatment group (P-value = 0.301) did not show a significant difference in all groups. The histology study also showed that the highest rose petals ointment has many developed hair follicles and denser collagen fibers like the standard group. Overall, it can be concluded that the rose petals methanol extract as an ointment has a wound-healing effect.

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