THE NEUROPROTECTIVE EFFECTS OF THE ETHANOLIC EXTRACT OF SYZYGIUM POLYANTHUM IN BENZENE-INDUCED RATS

ANDINI MANDIRA (2021) THE NEUROPROTECTIVE EFFECTS OF THE ETHANOLIC EXTRACT OF SYZYGIUM POLYANTHUM IN BENZENE-INDUCED RATS , TESIS, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

 

Benzene metabolites are also involved in its toxicity. The toxic and carcinogenic effects of benzene are caused by several factors such as the duration and level of exposure, mode of exposure, and individual susceptibility factors (age, gender, lifestyle, and pre-existing diseases). Syzygium polyanthum (Wight) Walp. or known as Syzygium polyanthum is a species of the Myrtaceae family which is used as a traditional medicine by various ethnic groups, especially in Southeast Asia such as Malaysia and Indonesia. This study aimed to determine neuroprotective effect of extract ethanol syzygium polyanthum. 44 rats were divided into eleven groups, each consisting of4 rats. The normalgroup was given only CMC (carboxy methyl celluloce), meanwhile, negativegroup 1 and 2 weregiven benzene 100 mg/kgbw every 6 and 3 days intraperitoneally. Furthermore, positive groups 1 and 2 were treated with vitamin c + benzene 100 mg/kgbw every 6 and3 days, respectively. Group I-6 rats were given the extract, namely 400, 600, and 4800 mg/kgbw + benzene 100 mg/kgbw every 3 and 6 day) during 21 day of the experiment. On day 22, the rats were injected with 1% ketamine while blood samples were taken directly from the heart. This was followed by Interferon Gamma and COX-2. The result shows that extract ethanol syzygium polyanthum can reduce the biomarker of Interferon gamma and COX-2 after induced benzene on rats.

 

JURNAL

KATEGORI JURNAL	Jurnal Internasional Bereputasi
TAHUN JURNAL	2021
VOLUME JURNAL	13
NOMOR JURNAL	1
NAMA PENERBIT	International Journal of Research in Pharmaceutical Sciences
NOMOR ISSN/ISBN	09757538
LAMAN PENERBIT (URL)	https://ijrps.com/index.php/home/index
LAMAN ARTIKEL (URL)	https://ijrps.com/index.php/home/article/view/13