THE ROLE OF PLATELET-RICH PLASMA TO SPERM QUALITY IN MALE PARTNERS UNDERGOING INFERTILITY TREATMENT

JESSELYN ANGELLEE (2021) THE ROLE OF PLATELET-RICH PLASMA TO SPERM QUALITY IN MALE PARTNERS UNDERGOING INFERTILITY TREATMENT , TESIS, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

For a period of time, PRP has been used to treat female with infertility, but little has been done to male with similar condition. Several studies suggested that hormones and growth factors contained in PRP may be beneficial for sperm, thus a prospective analytical study with a pretest-posttest design to assess the role of PRP to sperm concentration, motility, morphology, and DFI was conducted in 40 male partners undergoing infertility treatment from April-May 2021. Semen sample was collected from each patient to assess the sperm parameters and DFI, then 5 mL of blood sample were drawn for PRP. The parameters were compared between fresh samples and samples incubated with PRP for 1 hour. The results showed that semen samples incubated with PRP yield a significantly better quality (p=0.000) in terms of concentration (28.40±17.66 million/mL vs 35.74±21.37 million/mL), motility (37.90±15.43% vs 97.40±1.17%), progressive motility (0.30±0.65% vs 23.92±14.75%), morphology (2.65±0.66% vs 4.55±0.99%), and percentage of sperm with good fertilization ability (65% vs 97.5%). These results suggest that incubating semen samples with PRP may be considered as a choice of treatment for male with abnormal semen parameters undergoing assisted reproductive technologies (ART) cycles, such as intrauterine insemination (IUI) or in vitro fertilization (IVF).

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