POTENTIALS OF ROSE (ROSA DAMASCENA) PETALS AND RECEPTACLES EXTRACT AS ANTIOXIDANT AND ANTIHYALURONIDASE

DESI YUSTRA SARI DEWI (2020) POTENTIALS OF ROSE (ROSA DAMASCENA) PETALS AND RECEPTACLES EXTRACT AS ANTIOXIDANT AND ANTIHYALURONIDASE , TESIS, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

Free radicals affect aging by unspecific lead breakdown to macromolecules, like DNA, lipids, and proteins. The degradation of the extracellular matrix affects skin aging and correlated with the hyaluronidase enzyme. Rose (Rosa damascene) petal extract and rose receptacle extract can scavenge free radicals, thus hindering the aging process. This study examines phenolic and flavonoid content, the antioxidant, antihyaluronidase potential owned by rose petal extract (RPE), and rose receptacle extract (RRE) inhibiting skin aging. In this study, Hydrogen peroxide (H₂O₂) scavenging activity assay was done to analyze the antioxidant activity while the hyaluronidase inhibitory assay analyzed antiaging activity. The characteristic of RPE and RRE were measured the phenolics and flavonoids content. The phenolics content of RPE and RRE were 9.66 µg GAE/mg RPE and 4.31 µg GAE/mg RRE, respectively, while the flavonoids content of RPE and RRE respectively 1.22 µg QE/mg RPE and 0.59 µg QE/mg RRE. The median inhibitory (IC₅₀) of H₂O₂ scavenging of RPE (207.99 µg/mL) was more active than RRE (348.24 µg/mL). RPE’s antihyaluronidase (IC₅₀: 51.68 µg/mL) is as effective as RRE (IC₅₀: 51.98 µg/mL). Antioxidant and antiaging activities possessed by RPE and RRE are promising natural agents for aging therapy.

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