PANCREAS PROTECTIVE EFFECT ETHANOL EXTRACT OF CURCUMA ON RATS INDUCED DOXORUBICIN
RIZKI RAMADANI LUBIS (2021) PANCREAS PROTECTIVE EFFECT ETHANOL EXTRACT OF CURCUMA ON RATS INDUCED DOXORUBICIN , TESIS, UNIVERSITAS PRIMA INDONESIA
ABSTRAK
Chemotherapy drug exposure has been linked to an increased risk of type 2 diabetes, a condition marked by peripheral insulin resistance and reduced glucose-stimulated insulin secretion from pancreatic cells (GSIS = glucose-stimulated insulin secretion). The goal of this study is to see if the ethanol extract of Curcuma provides antidiabetic and pancreatic protection in doxorubicin-induced rats. This study was carried out in mice that were given 15 mg/kg of doxorubicin and 100 mg/kg, 300 mg/kg, and 500 mg/kg of Curcuma ethanol extract. The results showed that the ethanol extract of Curcuma at doses of 100 mg/kg, 300 mg/kg, and 500 mg/kg of body weight had a substantially different activity in lowering blood glucose levels (P0.05) as compared to the negative control group, which received only CMC-Na and doxorubicin. When compared to the negative control group, which received only CMC-Na and doxorubicin, the ethanol extract of Curcuma at doses of 100 mg/kg, 300 mg/kg, and 500 mg/kg of weight exhibited substantially different actions to reduce HbA1c levels (P<0.05). Kurkuma ethanol extract reduced the incidence of pancreatic cell histopathological damage.
PROSIDING
KATEGORI PROSIDING | Prosiding Internasional |
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LOKASI PROSIDING | Medan |
TANGGAL MULAI KONFERENSI | 2021-07-14 |
TANGGAL SELESAI KONFERENSI | 2021-07-16 |
NAMA PENERBIT | IEEE |
NOMOR ISSN/ISBN | 9781665441827 |
LAMAN PENERBIT (URL) | https://ieeexplore.ieee.org/ |
LAMAN ARTIKEL (URL) | https://ieeexplore.ieee.org/document/9537222 |