COMPARISON HEPATOPROTECTIVE EFFECT OF VIRGIN COCONUT OIL AND CURCUMA LONGA LINN AGAINST DOXORUBICIN INDUCED HEPATOTOXICITY IN WISTAR RAT

YENNY (2020) COMPARISON HEPATOPROTECTIVE EFFECT OF VIRGIN COCONUT OIL AND CURCUMA LONGA LINN AGAINST DOXORUBICIN INDUCED HEPATOTOXICITY IN WISTAR RAT , TESIS, UNIVERSITAS PRIMA INDONESIA

ABSTRAK

The liver is the main detoxification organ and the center of collecting toxins in the human body. Free radicals and metabolites can damage the liver. Semiquinon was oxidized from doxorubicin but because an unstable metabolite, so in a process  is converted back to doxorubicin by release reactive oxygen species . Reactive oxygen species will damage DNA, cell membrane, lipid peroxidation and apoptotic cell death include hepatocyte. This study aimed to compare the hepatoprotective activity of Longa Curcuma and Virgin Coconut Oil (VCO), by observing the activity of SGOT and SGPT. Curcuma longa and VCO experiments were carried out on 15 male white rats induced with doxorubicin. This study has five groups consists of negative control group, positive control group, Group I (doxorubicin 5 mg / kgbw + 6 ml VCO), Group II (doxorubicin 5 mg / kgbw + Curcuma longa 100 mg / kg BW), Group III (doxorubicin 5 mg / kg + 6 ml VCO + Curcuma longa 100 mg / kg BW). Furthermore, measurements of the SGOT and SGPT levels were carried out to obtain changes in the histopathological value of rat liver. The measurement results showed that the lowest changes in the SGOT and SGOT activity were found in group III about 53.30 ± 1.44 and 140.850 ± 0.56, respectively, towards the negative control group about 53.77 ± 0.99 and 130.850 ± 0.63 , respectively. The SGOT and SGPT levels of Group III greatly differ when compared with positive controls ie 106.20 ± 1.73 and 215.125 ± 3.33, respectively. Doxorubicin greatly increases the activity of SGOT and SGPT, and causes damage to liver tissue, but by giving a combination of the VCO and Curcuma Longa produces significant hepatoprotective effects.

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